has not been explicitly explored. Recently, investigators have started to study the abnormal coupling in cognitive control circuits as a potential intermediate phenotype and preliminary results suggest a decrease of the coupling within prefrontal regions in healthy relatives of patients with schizophrenia [39]. Few studies so far have explored the modulation of risk genes on cognitive control circuits, reporting increase [40], decrease [41] or no effect [42] on ACC activity (Supplementary Table 2.B; Figure 2.B).
