variants for European and African ancestries (Supplementary Figure 5). In ADH1C, extreme ΔF values were observed for Asian ancestry (i.e., ΔF>0.6), and most of the Asian ΔF peaks are genome-wide significant variants for AD symptom counts (Supplementary Figure 6). Both ADH1B and ADH1C ΔF top values are included in the top 0.1% of the distribution of Asian ΔFs. To check whether the high ΔF values of ADH1B and ADH1C in Asians and PDLIM5 in Africans are due to human demographic history or to natural selection processes, we verified the integrated Haplotype Score of these loci using the Haplotter application [35]. Significant signatures of natural selection are confirmed in Asians for ADH1B (p = 0.011) and ADH1C (p = 0.009) (Supplementary Figure 7), while a nonsignificant outcome was observed for PDLIM5.
