Chunk #47 — FINDINGS — Relation of Risk Factors to Cognitive and Motor Outcomes, Disability and Death — Anxiety-Related Traits: Neuroticism, Anxiety, Childhood Adversity, and Harm Avoidance
Neuroticism was associated with an increased risk of AD and with a more rapid rate of cognitive decline among persons without dementia, and risk of MCI and change in cognition among persons without dementia or MCI [126,127]. Interestingly, the association was most robust for episodic memory and executive abilities (i.e., working memory, perceptual speed) [128]. Neuroticism is a broad trait. Of its facets, anxiety and vulnerability to stress were most strongly related to cognitive decline [128]. Neuroticism was also associated with change in motor function [129]. Anxiety is also associated with risk of dementia [128]. Interestingly, childhood adversity, in particular emotional neglect and parental intimidation, was associated with neuroticism [72].
