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Chunk #8 — Methodological Considerations — Inferring Population Structure

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Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations.
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if there is an insufficient number of other individuals who fall into a similar cluster. These assignment methods will not provide - and are not intended to provide - detailed ancestral background information for each individual. Rather, they provide a working solution to reduce false positives due to population stratification (Hellwege et al., 2017). We stress that sample group assignment and identifying appropriate reference population panels can be difficult, particularly for admixed ancestry, thus requiring careful inspection of data and methods (Medina-Gomez et al., 2015).