In terms of estimated heritability from common variation, our results compare favorably with previous studies of OCD. Published estimates of SNP-based heritability, based on different samples from different populations, range from 25–43% (5, 15, 16). Thus, all studies have converged on a substantial contribution of common variation to the heritability of OCD, showing notable consistency. There are some differences, however. Notably, the recent study by Davis and colleagues suggest that only SNPs with substantial frequency in their population sample (MAF > 0.05) contribute to this heritability and the contribution to heritability tends to increase with increasing MAF.
