The current study demonstrates that polygenic liability to cannabis use was nominally associated with cannabis use (ever) and with DSM-5 CUDsx in COGA, a deeply phenotyped family sample enriched for individuals with substance use disorders. In addition, moderation of this polygenic risk for cannabis use was observed with one well-known risk factor, trauma exposure. Weaker evidence of moderation by frequency of religious service attendance was also observed. These findings provide the first evidence that trauma may potentiate polygenic risk for CUDs, while for some groups, religious service attendance may serve to dampen genetic susceptibility.
