other difficult-to-treat anxiety disorders. Moreover, proof-of-concept studies such as this will provide the necessary bioassay of THC’s putative anxiolytic effects and enhance the pace of drug development of cannabinoid modulators (agonists such as THC, or FAAH inhibitors such as URB597). The present study is a critical translational first step towards the development of cannabinoid modulators as an adjunctive strategy to exposure-based therapies to augment extinction learning and prevent the return of fear memories in people suffering from anxiety disorders.