sensitivity. Interestingly, the gain in sensitivity was not always the highest when we weighted the shared xQTL SNPs. Also, compared to weighting the DGN eQTL SNPs, weighting the union of all xQTL SNPs found in this study identified more additional independent susceptibility SNPs for a majority of the tested GWAS datasets, which demonstrates that additional signals are captured by mQTL and haQTL SNPs. In particular, weighting the xQTL SNPs found 22, 18, and 9 additional independent SNPs for schizophrenia, height, and inflammatory bowel disease, respectively, compared to no weighting. In contrast, weighting the DGN eQTL SNPs found only 9, 3, and 2 additional independent SNPs. In fact, weighting just the ROSMAP eQTL SNPs identified 17 additional independent SNPs for schizophrenia, which illustrates the presence of eQTLs in our data that are enriched in brain diseases and not observed in blood.
