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Chunk #21 — MATERIALS AND METHODS — Data Analysis — Quadrivariate Model

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Common genetic contributions to alcohol and cannabis use and dependence symptomatology.
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A series of sub-models examining the statistical significance of A, C, and E were compared to the full model to derive the best-fitting quadrivariate model. Sub-models were tested by calculating the difference between the -2 log likelihood fit of the full model and nested sub-model, which is distributed as chi-square for the given degrees of freedom.