The increases in theta-gamma PAC strength we report here are consistent with the handful of previous studies investigating the effects of other drugs commonly associated with substance abuse disorders on PAC. Notable among them are several animal models of addiction based on conditioned place preference (CPP). The CPP paradigm employs a test chamber divided into two sides separated by a wall; in the conditioning stage, animals are administered a drug or other reward prior to placement in one side of the chamber in which they are restricted, and no reward when placed on the opposite side. During the post-conditioning stage, animals are allowed unrestricted access, without reward treatment, to both sides of the chamber during which time spent on either side is measured (Fattahi et al., 2023). Animals spend more time on the side of the test chamber in which they had undergone repeated reward-pairing, having learned to associate the side-specific sensory stimuli with reward. In one such study, Zhu and colleagues gathered local field potentials (LFP) from the prelimbic area of mPFC in male rats before and after CPP
