children (OR = 1.171; 95% CI = 0.947–1.448; one-sided P = 0.066). A similar qPCR-based analysis in the replication sample revealed a directionally consistent finding (OR = 1.214; 95% CI = 0.959–1.537; one-sided P = 0.056). Finally, we performed a joint analysis of all case-parents trios (discovery and replication sample) to increase the precision of the estimator, resulting in an OR of 1.190 for the deletion allele (95% CI = 1.016–1.394; one-sided P = 0.015).
