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Chunk #3 — Methods — Sample

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The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure.
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This study includes 286 unrelated individuals from the Collaborative Study on the Genetics of Alcoholism (COGA) pedigrees [5]. We preferentially selected founders; however, in cases where 2 founders had large amounts of missing data, we selected the offspring for whom the most data was available. The self-reported race of these 286 individuals was as follows: 245 European Americans, 26 African Americans, 12 European American/Hispanics, and 3 African American/Hispanics. Each of these individuals was genotyped for the 328 STRPs from COGA, 4,720 SNPs from the Illumina linkage panel, and 11,120 SNPs from the Affymetrix mapping array which were prepared for Genetic Analysis Workshop 14 [5].