Another similarity between the PheWAS and the genetic correlations was the positive association between POU and pain phenotypes measured in EHR, such as acute pain (OR = 1.05, p = 2.09E−04) and chest pain (OR = 1.04, p = 8.90E−04). POU was also significantly associated with various psychiatric disorders, including mood disorders (OR = 1.08, p = 1.01E−11), anxiety disorders (OR = 1.09, p = 1.98E−11), depression (OR = 1.07, p = 1.29E−08) and posttraumatic stress disorder (OR = 1.18, p = 1.60E−07).
