Despite the growing literature on cannabis use in BD, less is known about CUDs in this population, especially in more acutely ill samples. Within community samples, as in the general population, a 12-month CUD diagnosis within BD has been linked to male sex and younger age [6,7,19]. CUD comorbidity in BD has also been associated with earlier age of BD onset, more frequent mood cycling, and greater rates of comorbid other SUDs, including nicotine dependence, alcohol use disorders (AUDs), and non-cannabis drug use disorders [6]. Additional data reveal greater rates of disability [20] and poorer physical quality of life [6] in community samples of individuals with BD and comorbid CUDs, and some [20], but not all [6,21], have demonstrated elevated risk for suicide attempt among those with BD and a comorbid CUD.
