We applied weighted genome coexpression network analysis within the PPD and non-PPD women separately, as well as within the mouse E2 DMR data to ascertain the normal coregulation pattern of HP1BP3 and TTC9B genes. The pattern of gene coregulation was positively correlated between HP1BP3 and TTC9B in non-PPD cases and mice, but anticorrelated in PPD cases (Supplementary Figure 6), and is consistent with the proposed heightened sensitivity to E2-mediated epigenetic reprogramming in the PPD group.
