To achieve higher resolution, we analyzed a subset of 153 hPSC and tissue samples using the 450K DNA Methylation array. In order to identify unique epigenetic features in 17 distinct tissue types (e.g. brain, heart, kidney) and hPSCs, we filtered for CpGs that were differentially methylated in each tissue or cell type compared to all other samples with a Δβ > 0.5 (p < 0.05).
