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Chunk #4 — Methods — Diagnostic interviews

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Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls.
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Daughters and mothers were administered a structured clinical interview, Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL), about the daughters. Both informants needed to report an absence of current/past mental health disorders in the daughters to be eligible for participation. Mothers were also administered a clinical interview, the Structured Clinical Interview for the DSM–IV (SCID), to assess their Axis I disorders. Dyads were eligible to participate if the mothers had experienced either (1) no current/past disorders (low early adversity); or (2) at least two major depressive episodes during their daughter's lifetime but were currently in remission (high early adversity). Approximately 35% (n=45) of the mothers had recurrent depression; the remaining 65% (n=84) had no history of mental health disorders. The racial/ethnic make-up of the high adversity sample was 71.1% (n=32) Caucasian, 15.6% (n=7) biracial, 4.4% (n=2) Asian American, 6.7% (n=3) Latina, and 2.2% (n=1) African American.