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Chunk #54 — Online Methods — Simulations with Real Genotypes

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Leveraging population admixture to characterize the heritability of complex traits.
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We split the genotypes from 5,129 distantly related CARe individuals into two groups. The common group contained those SNPs with MAF > 5% in both CEU and YRI. The uncommon group contained all other SNPs (i.e. MAF < 5% in either or both of CEU and YRI). The genotype kinship matrix K was constructed over the common SNPs and the local ancestry kinship matrix Kγ was constructed using the local ancestry called at every 5th common SNP.