diazozine version of photoswitchable GIRK openers, CLOGO (Cyclic azobenzene LOGO) [36]. CLOGO has an inverted pharmacological sign (inactive in the dark and active upon light exposure) which makes it more suitable as pharmacological tool. CLOGO reduced action potential firing in mouse neurons (Table 1) [36]. The main drawback of these photoswitchable GIRK modulators, however, is their lack of selectivity, since they act with similar potency on both GIRK1/GIRK2 and GIRK1/GIRK4 in the thallium flux assay [34–36].
