After correcting for the effects of batch, age, and RIN, the hierarchical clustering of expression data from nearly 18,000 genes generated 27 different modules (Supplementary Figure 1). Trait-module correlation analyses identified five modules that were significantly correlated to at least one alcohol-related trait (Fig. 2). Of these five modules, the thistle2 module (containing 72 genes), was negatively correlated with alcohol dependence and other alcohol-related traits. The brown4 module (containing of 795 genes) was positively correlated with AD, AUDIT, alcohol consumption and duration of alcohol use.
