Among the 31 known HGB, HCT, or WBC count associations testable with TOPMed freeze 5b, our imputed/discovery cohorts confirmed 84% of these previously reported findings with a consistent direction of effect, using a stringent genome-wide significant threshold of p<5x10-8. Using more lenient p-value thresholds, we could replicate 94% (p<5x10-6) and 100% (p<0.05) of the previously reported findings with the same direction of effect. While these results help confirm the overall validity of our hematological trait association results, it is important to note for these comparisons that many of the samples included in the current TOPMed freeze 5b imputed genome-wide association analysis were also used in the publications originally reporting associations in AA and Hispanic/Latino individuals.
