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Chunk #44 — Online Methods — Effects of lung function associated variants on other traits

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Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
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To identify whether the novel and previously reported lung function-associated variants had been reported in previous GWAS as associated with traits other than lung function and COPD, we queried the GWAS Catalog56 (last update: 13/03/2016, downloaded on 17/03/16) and GRASP57 (v2.0, downloaded on 17/03/16) for genome-wide significant (P<5x10-8) signals using the 95% credible set (if calculated) or all proxy SNPs (r2>0.8) within 2Mb of the top variant in our data.