the development of AUD. Importantly, ample evidence shows that age of onset of regular drinking is associated with increased alcohol problems during adult life and that parietal P3 amplitude is a biomarker for AUD-risk. Given that FH is an index of risk that can be assessed early in individuals’ lives, it is meaningful to examine its associations with risk factors that occur sooner in the stages of AUD development. Therefore, these findings can be of great value in informing the planning and development of early prevention and intervention strategies. Lastly, we took advantage of COGA’s multimodal data that are available for a large and ethnically diverse sample with ~equal numbers of males and females, allowing the comparison of FH measures and their associations with clinical, behavioral, and neural phenotypes, across gender, race/ethnicity, and in families with a range of density of FH of AUD, with substantial statistical power. Therefore, our findings may have great applicability in population-based contexts that examine FH of AUD.
