a non-parametric bootstrap method with 1000 resamplings. The bootstrapping process is described in Chorlian et al. (2017, p. 28). The regression method used in the calculation of the genotypic effect on the trajectories has the power to reliably detect effect sizes of greater than 0.1 based on the large number of subjects and observations included in the calculations of each parameter. Effect sizes of the major allele of significant SNPs typical of GWAS results in Kang et al. (2012) are of absolute value between 0.1 and 0.2.
