In this report, we extend our analysis of clonal mosaic abnormalities in the autosomes to 57,853 individuals (including those previously published16). We tested 31,717 cancer cases and 26,136 cancer free controls for evidence of mosaic abnormalities using genome-wide SNP array data generated as part of 13 distinct cancer GWAS drawn from 48 epidemiological case-control and case-cohort studies (Supplementary Table 1). DNA samples were extracted from blood or buccal samples using a variety of collection and extraction techniques and genotyped using one or more Infinium Human SNP arrays from Illumina Inc. (including versions of Hap300, Hap240, Hap550, Hap610, Hap660, Hap1, Omni Express, and Omni1). Genotype clusters were empirically estimated in 45 batches to optimize accuracy while minimizing potential batch effects (Online Methods).
