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Chunk #25 — Discussion

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Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls.
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of findings, there is clear convergence of results across studies in support of the notion that Val158Met genotype plays a particularly important role in the structural development of lateral prefrontal, cingulate and superior temporal cortices. These findings in HCs also overlap those of our prior preliminary report (Shaw et al., 2009). However, our present study uses an expanded and largely independent sample of HCs, with a greater density of imaging data (33 vs 23 scans per year of age-range) over a tighter age range (9 to 22 years vs 3 to 22 years), to identify more symmetric and dynamic relationships between Val dose and cortical maturation in typical development.