the null expectation of 9NR:9R is marginally significant by a one-sided Fisher’s exact test (p = 0.0375), it is not persuasive evidence in a linkage setting. However, when 50 marker-identical families are pooled, this minor nonrandom segregation is telescoped into 750NR:150R, which is a highly significant deviation from the 450NR:450R expected under the hypothesis of no linkage. We believe this is the explanation of the false-positive signal at CDCA2.
