Genome-wide cox-proportional hazards analysis with 4,058,415 SNPs identified genome wide significant SNPs (p < 5.0 × 10−8) in 3 loci: 35 SNPs clustered on chromosome 3, 2 on chromosome 5 and one on chromosome 12 (Table 2, Fig. 2). A total of 225 SNPs showed suggestive association at p < 1.0 × 10−5 (please see supplemental e Table 1 for SNPs with genome-wide suggestive association1). Among these 225 SNPs, 95 SNPs were in strong LD (D’=1; r2 > 0.8) with the most significant SNPs on chromosomes 3, 5 and 12.
