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Chunk #7 — Materials and methods — Clinical and genetic characteristics of the autistic subjects

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The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes.
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and the Woodcock-Johnson Tests of Achievement-Revised (Table 2). Eight subjects were diagnosed with intellectual disability, usually in the range from mild to severe (61%). Six of 13 autistic subjects had seizures (46%). In five cases, the age of onset of seizures was from 14 months to 5 years of age. A 23-year-old autistic male had only one seizure, which was reported as the cause of his death. In one child, an abnormal EEG was detected, but without seizures.Table 2Behavioral and neurological signs, and the type and topography of developmental abnormalitiesBrain bank #Psychiatric disorders and neurological symptomsMental retardation (MR)Seizures age of onsetType and topography of developmental abnormalitiesIBR425-02Hyperactivity. Tantrums. Self-injurious behavior––No changesUMB-1627Aggression––Focal neuronal heterotopia in white matter of the anterior cingulate gyrusB-6403––14 monthsSubependymal nodular dysplasia in the wall of the occipital horn of the lateral ventricle. Two periventricular nodular heterotopias (2 and 4 mm in diameter) near the frontal horn of the lateral ventricle. Tuber-like expansion of the tail of caudate nucleus into the lumen of the ventricle. Flocculonodular dysplasiaB-5666––Abnormal EEG; no seizuresCortical dysplasia in the middle and inferior temporal gyri with focal dyslamination, clustering of dystrophic neurons and severe local neuronal deficits. Several focal dysplastic changes within CA. Flocculonodular dysplasia affecting