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Chunk #15 — MATERIALS AND METHODS — Participant Selection for Association Studies

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Association study of 182 candidate genes in anorexia nervosa.
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illness was chosen due to the fact that the presence of binge eating has been identified as a distinguishing feature within the AN diagnostic category [Herzog et al., 1996]. This sample comprised 415 individuals with RAN, 266 with PAN, and 6 with subthreshold AN with no binging or purging. The third analysis included the narrowest definition of illness, namely Restricting AN (N = 421), based on previous linkage analyses that identified significant and suggestive linkage signals based on a case definition of Restricting AN [Devlin et al., 2002; Grice et al., 2002]. This sample included 415 individuals with RAN and 6 individuals with subthreshold AN with no binging or purging. The AN with No Binge Eating sample was a subset of the All AN sample, and the Restricting AN sample was a subset of the AN with No Binge Eating sample.