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Chunk #11 — Material and methods — Polygenic Risk Score (PRS) sample, measures, and statistical analyses

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Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders.
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Data used to calculate the polygenic risk score (PRS) from the PGC-PTSD Freeze 2 summary statistics were available for only EA participants (N = 3533 trauma-exposed individuals). In contrast, both EA and AA participants comprised the MVP-PTSD PRS (EA = 3522 and AA = 1678 trauma-exposed individuals). Descriptive statistics for the PGC-PTSD PRS and MVP-PTSD PRS analytic subsamples are displayed in Supplementary Tables 2 and 3, respectively. Additional measures used in both PRS analyses included lifetime DSM-IV alcohol dependence (endorsement of 3 or more out of 7 symptoms).