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Chunk #10 — RESULTS

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Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.
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The average scores (± standard deviations) across the temperament subscales were as follows: 9.1 (±4.4) for hyperthymic, 10.8 (±4.1) for dysthymic, 12.7 (±5.5) for cyclothymic, 7.6 (±4.8) for irritable, and 13.0 (±6.4) for anxious. As might be expected, significant correlations were observed between four of the five temperaments, as shown in Table 1. Relatively high correlations (r=0.44–0.68, p<0.001) were observed between the dysthymic, cyclothymic, irritable, and anxious temperaments. Weaker correlations were observed for the hyperthymic temperament with the dysthymic (negative), cyclothymic, and irritable temperaments (r=0.14 to 0.24).