Chunk #9 — A brief review of major methods used to evaluate alcohol reaction phenotypes — Examples of measures of alcohol reactions across different populations
SRE and alcohol oral single dose challenge-based low LRs predict heavy drinking up to 35 years later in men and women in most studies in the U.S., Australia, U.K., and Germany (e.g., Daeppan et al., 2000; Ehlers et al., 1999; Eng et al., 2005; Gonçalves et al., 2017; Heath et al., 1999; Hinkers et al., 2005; Quinn and Fromme, 2011; Schuckit et al., 2007, 2008). High stimulating effects of alcohol on alcohol challenges robustly predict increases from baseline in heavy episodic (binge) drinking and alcohol problems at 2- and 6-year follow-ups (e.g., King et al., 2011, 2014, 2016).
