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Chunk #16 — Results — Multivariate GWAS. — Empirical results.

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Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis.
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We identified nine hits for the Neurodevelopmental disorders factor (Supplementary Table 20), three of which were in LD with hits for ADHD or MDD, and two of which were novel relative to the contributing univariate GWASs. There were seven hits for the Neurodevelopmental QSNP statistic, many of which appeared to be specific to AUT (Supplementary Table 22). We identified 44 independent hits for the Internalizing disorders factor, six of which were unique of hits from the contributing univariate GWASs (Supplementary Table 23). Three loci were identified for the Internalizing factor-specific QSNP statistic, all three of which were in LD with hits for ALCH (Supplementary Table 25). We note that the discrepancy in the number of univariate MDD hits (109) relative to the number of Internalizing factor hits (44) can be attributed to a combination of signal specific to MDD and splitting the MDD signal across two factors (Supplementary Fig. 38).