Although some functional implications may be gleaned by examining GM at the lobar level, a significant advance was gained with the development of techniques able to measure cortical thickness at a high level of resolution, making it possible to describe structural differences with a greater degree of spatial detail potentially more suitable for relating to functional characteristics. Challenges to measurement of cortical thickness include accurate removal of overlying skull, modeling the cortical surface in regions where opposing sulcal surfaces may touch, and individual differences in cortical morphology.
