These Connectivity Score metrics constitute a statistical framework that provides a holistic quantification of the relationship between a query and a perturbagen, as opposed to merely sorting by degree of similarity. Additionally, while the Connectivity Scores are generated on each cell type individually, we summarize those scores across all profiled cell types and thus provide a measure of robustness. Importantly, this analytical approach is platform-independent, allowing users to create query signatures from any gene expression platform.
