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Chunk #2 — Introduction

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Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.
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al., 2007) blood (Nalls et al., 2011a), subcutaneous adipose tissue (Emilsson et al., 2008) and brain (Gibbs et al., 2010, Heinzen et al., 2008, Liu et al., 2010a, Myers et al., 2007, Webster et al., 2009). For at least some loci, eQTLs are found consistently in both transformed cells and in primary tissues (Bullaughey et al., 2009). Overall, this data might suggest that functional annotation of GWAS loci can be performed in any convenient tissue.