Chunk #37 — Results — Decitabine exposure leads to Mecp2e1 upregulation but its withdrawal downregulates both Mecp2 isoforms to different extents

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Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells.

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Taken together, our data so far indicate that a single administration of decitabine for 48 h induces Mecp2e1/MeCP2E1, MeCP2 (total) expression, whereas its withdrawal downregulates Mecp2 (total)/MeCP2 (total), Mecp2e1/MeCP2E1, and Mecp2e2 expression with minimal change in NSC differentiation.