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Chunk #20 — Discussion

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Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders.
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We present the first genome-wide eQTL mapping study performed exclusively on the prenatal human brain. Through deep RNA sequencing, we have been able to interrogate eQTL at the individual transcript as well as whole gene level, providing a more precise elucidation of common genetic influences on gene expression in the developing brain and the molecular differences that could confer susceptibility to neuropsychiatric disorders.