LDL-c is a known causative risk factor for CAD as confirmed by RCTs6,7. We found that LDL-c had a significant risk effect on dyslipidemia (OR = 3.36) and CVD (OR = 1.22) in the community data, and CAD (OR = 1.50) in the case–control data (Fig. 2). TG had a significant risk effect on dyslipidemia (OR = 2.09), hypertensive disease (OR = 1.24) and CVD (OR = 1.14) in the community data, and CAD (OR = 1.33) in the case–control data (Fig. 2). The effects of TG on diseases were largely consistent with those for LDL-c (Supplementary Fig. 10b), despite the modest phenotypic correlation between the two traits (rp = 0.19 in the ARIC data). Both LDL and TG had significant risk effects on disease count in the community data (Fig. 2).
