Figure 2 provides an example of the information displayed on the study-trait page. The first section provides an overview of the study sample size and links to the original publication (Figure 2A). The second section provides a Manhattan-like plot that displays the independently associated variants that reached GWAS significance threshold (Figure 2B). A table provides the effect sizes of the alternative allele and the genes likely to be involved at each susceptibility locus prioritised by the statistical genetics analysis pipelines (colocalisation, L2G score, and closest gene) (Figure 2C). Using the ‘compare studies’ button on the study page, users can also compare the Manhattan plot for the root study with Manhattan plots for other studies to identify shared independent loci across the genome (https://genetics-docs.opentargets.org/how-to-use-open-targets-genetics-starting-with/multiple-traits-or-diseases) (Figure 2D).
