The His48 allele is also associated with lower alcohol consumption as measured by the subjects’ lifetime maximum alcohol consumption in a 24-hour period (β = −0.28 (95% CI −0.35, − 0.20), p value = 3.24 × 10−13) (Table 3). A similar association is seen in both European American and African American subjects. These findings are consistent with, but exceed in magnitude, those from a prior report of association between His48 and maximum drinks consumed in a 24-hour period22.
