Chunk #21 — MATERIALS AND METHODS — Statistical Analyses — UKB:

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Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples.

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For illustrative purposes, PRS were also split into quartiles for COGA, ALSPAC, and UKB, and the odds of having an AUD diagnosis (DSM-IV alcohol dependence in COGA and ALSPAC, ICD-9/ICD-10 alcohol related codes in UKB) was calculated in each quartile using the lowest quartile as the reference group.