Of the 483 participants, 262 (54.2%) reported ever using cannabis. Forty-nine percent of the exposed individuals reported first using cannabis by 17-years-old and 29.4% reported using cannabis >100 times (eFigure 1). Cannabis users were significantly more likely to be male, to be non-White, to report lower income, to report greater alcohol, cigarette, and other illicit drug use, to report more childhood conduct problems, to be less agreeable and more impulsive, and to show steeper delay discounting as compared to never users (Table 1). Similar relationships were also observed with increasing frequency of use and decreasing age of onset (eTable 3). Descriptive statistics and inter-correlations among brain volumes are presented in eTable 4 and inter-correlations among all covariates are in eTable 5.
