EXL-1 is expressed in body muscle and coloemocytes whereas EXC-4 is localized to the excretory canal cell, hypodermis, sheath cells, rectal gland and vulval cells (Berry & Hobert, 2006). Although the connections between these various cells or tissues and ethanol behavior in worms are not immediately obvious, the distinct patterns of EXL-1 and EXC-4 expression could contribute to the different ethanol-related behaviors observed in exl-1 and exc-4 mutants. Similarly, it is possible that Clic4 over-expression in regions of the mouse brain other than the PFC could produce varying effects on LORR or even other ethanol behavioral phenotypes.
