Despite this accumulating preclinical and emerging human association evidence22–23, the moderating effects of eCBS on the link between chronic uncontrollable stress and anhedonia has only been infrequently examined and replicated. The goal of this study was to investigate whether rs1049353 in CNR1 is involved in stress adaption of this nature. We (a) examined whether carriers of the minor allele (AA/AG) of rs1049353 who were exposed to childhood physical abuse have a differential likelihood of self-reported lifetime anhedonia compared with those homozygous for the major allele (GG); (b) examined whether this effect extended to a diagnosis of major depressive disorder with anhedonia; (c) examined whether our results were specific to childhood physical abuse; and (d) replicated this finding in an independent sample.
