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Chunk #30 — RESULTS — Genotype Imputation in Admixed Populations

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Local and global ancestry inference and applications to genetic association analysis for admixed populations.
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ancestral populations, e.g., the African, European, and Asian reference panels, resulted in poor genotype imputation quality for the admixed GAW18 samples. Interestingly, the reference panel consisting of admixed individuals from GAW18 that closely matched the ancestry of the sample individuals had higher imputation accuracy than all of the 1kGP reference panels considered, but this panel also resulted in higher missing genotype call rates.