visual processing) and in the same anatomical neighborhood (e.g., the occipital cortex) [68]. Thus, our results supported the notion that the functionally related regions or brain systems (e.g., the default mode system and the control system) emerge during development in childhood and adolescence [69], [70]. These results were also consistent with previous findings that the organization of multiple functional networks shifts from a local anatomical emphasis in children to a more distributed architecture in young adults, indicating the maturation process of the functional systems [59]. Our findings also provided some implications for understanding the inverse trajectories with advancing age (e.g., the decreased local efficiency) in functional [36] and structural [10], [37] brain networks. Moreover, the stable global efficiency in children might be associated with the fact that the path length of the functional brain networks in early childhood was already as short as those of random networks, as previous studies indicated [59], [60]. Furthermore, our results of the age-related increase in small-worldness indicated that the topological organization of the functional brain networks developed in healthy children to promote an optimal balance between segregation and integration for robust and dynamic information processing in the human brain [71]. Notably, statistical comparisons were
