We ran gene-property analyses using MAGMA on the EXT-minus-23andMe summary statistics. The Spearman rank correlation of the point estimates from the MAGMA 54 tissues-specific gene expression profiles on the down-sampled and restricted data multivariate GWAS summary statistics was 0.98, suggesting a comparable pattern of gene-tissue expression (Table S3 and Figure S5). The Spearman rank correlation of the point estimates from the MAGMA gene expression profiles across 11 brain tissues and developmental stages also suggested great similarity (r = 0.98) (Table S4 and Figure S6). Furthermore, the same 14 tissues, and three developmental stages, remained significant after Bonferroni-correction in the down-sampled analysis (Table S3–4). This evaluation showed that, in the case of EXT-minus-23andMe, the down-sampled gene-property analyses led to similar biological insights as those from the original paper (Karlsson Linnér et al. 2021).
