locus. SNP rs1948 was recently associated with the tolerance factor of the Nicotine Dependence Syndrome Scale (NDSS) (P = 0.0071) [Broms et al., 2012] and SNP rs684513 (major allele) has been previously associated with nicotine dependence [Winterer et al., 2010] and lung cancer risk [Amos et al., 2010]. Lori et al found an association with FTND of this CHRNA5 SNP [Lori et al., 2011]. These meta-analysis results support previous findings showing a protective effect of the minor allele for AOS (P = 0.015, beta = 0.034).
